mouse KDM2B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse KDM2B.
shAAV-262760
AAV-m-KDM2B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse KDM2B (lysine (K)-specific demethylase 2B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2
Description (Vector)
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Gene ID
30841
Gene Name (Vector)
lysine (K)-specific demethylase 2B
Gene Symbol
KDM2B
ORF Size (aa)
2331
ORF Size (bp)
2331 bp
RefSeq ID
NM_001003953
RefSeq Synonyms
NM_013910, NM_001005866, NM_001003953, BC065090, BC057622,
Species
mouse
UniGene ID
Mm.86406
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.