mouse KCNQ1 shRNA silencing AAV

Name 
AAV-m-KCNQ1-shRNA
Cat No 
shAAV-262702
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Kcnq1.

shAAV-262702
AAV-m-KCNQ1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Kcnq1 (potassium voltage-gated channel, subfamily Q, member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AW559127; Kcna9; KVLQT1
Description (Vector)
Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Gene ID
16535
Gene Name (Vector)
potassium voltage-gated channel, subfamily Q, member 1
Gene Symbol
Kcnq1
ORF Size (aa)
2007
ORF Size (bp)
2007 bp
RefSeq ID
NM_008434
RefSeq Synonyms
NM_008434, BC055304, BC045142,
Species
mouse
UniGene ID
Mm.453037

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.