mouse IRS4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Irs4.
shAAV-262386
AAV-m-IRS4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Irs4 (insulin receptor substrate 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IRS-4
Description (Vector)
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.
Gene ID
16370
Gene Name (Vector)
insulin receptor substrate 4
Gene Symbol
Irs4
ORF Size (aa)
3651
ORF Size (bp)
3651 bp
RefSeq ID
NM_010572
RefSeq Synonyms
NM_010572, BC150782,
Species
mouse
UniGene ID
Mm.261591
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.