mouse IRF2 shRNA silencing AAV

Name 
AAV-m-IRF2-shRNA
Cat No 
shAAV-262364
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Irf2.

shAAV-262364
AAV-m-IRF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Irf2 (interferon regulatory factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
9830146E22Rik; AI646973; interferon regulatory factor 2; Irf-2
Description (eCommerce)
Interferon regulatory factor 2 (IRF2) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. Like IRF1, IRF2 binds the upstream regulatory regions of the type I IFN gene. IRF2 has been found to be critical to the development of myeloid dendritic cells.
Description (Vector)
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Gene ID
16363
Gene Name (eCommerce)
interferon regulatory factor 2
Gene Name (Vector)
interferon regulatory factor 2
Gene Symbol
Irf2
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1050
Protein Name (eCommerce)
Interferon regulatory factor 2
RefSeq ID
NM_008391
RefSeq Synonyms
NM_008391, BC110666, BC006577,
Research Areas
Apoptosis,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
mouse
Target Sentence
Interferon regulatory factor 2 (IRF2) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. Like IRF1, IRF2 binds the upstream regulatory regions of the type I IFN gene. IRF2 has been found to be critical to the development of myeloid dendritic cells.
UniGene ID
Mm.1149
UniProt ID (eCommerce)
P23906

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.