mouse IKBKG shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ikbkg.
shAAV-262074
AAV-m-IKBKG-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ikbkg (inhibitor of kappaB kinase gamma). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110037D23Rik; AI848108; AI851264; AW124339; IKK[g]; NEMO
Description (Vector)
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Gene ID
16151
Gene Name (Vector)
inhibitor of kappaB kinase gamma
Gene Symbol
Ikbkg
ORF Size (aa)
1236
ORF Size (bp)
1236 bp
RefSeq ID
NM_010547
RefSeq Synonyms
NM_178590, NM_010547, NM_001161424, NM_001161423, NM_001161422, NM_001161421, NM_001136067, BC021431,
Species
mouse
UniGene ID
Mm.12967
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.