mouse ICOS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Icos.
shAAV-261832
AAV-m-ICOS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Icos (inducible T cell co-stimulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AILIM; CCLP; CRP-1; H4; Ly115
Description (Vector)
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Gene ID
54167
Gene Name (Vector)
inducible T cell co-stimulator
Gene Symbol
Icos
ORF Size (aa)
603
ORF Size (bp)
603 bp
RefSeq ID
NM_017480
RefSeq Synonyms
NM_017480, BC034852,
Species
mouse
UniGene ID
Mm.42044
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.