human GLRB Over-expression AAV

Name
AAV-h-GLRB

Cat No
AAV-209994

Availability
4-5 weeks

This is an AAV expressing Human GLRB.

AAV-209994

AAV-h-GLRB

Ready-to-use AAV expressing Human GLRB (glycine receptor beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HKPX2

Description (Vector)

GLRB encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

Gene ID

2743

Gene Name (Vector)

glycine receptor beta

Gene Symbol

GLRB

HGNC ID

HGNC:4329

ORF Size (aa)

1494

ORF Size (bp)

1494 bp

RefSeq ID

NM_000824

RefSeq Synonyms

NM_001166061, NM_001166060, NM_000824, BC032635,

Species

human

UniGene ID

Hs.32973

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.