mouse HGS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Hgs.
shAAV-261275
AAV-m-HGS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Hgs (HGF-regulated tyrosine kinase substrate). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Hgr; Hrs; tn; ZFYVE8
Description (Vector)
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Gene ID
15239
Gene Name (Vector)
HGF-regulated tyrosine kinase substrate
Gene Symbol
Hgs
ORF Size (aa)
2328
ORF Size (bp)
2328 bp
RefSeq ID
NM_008244
RefSeq Synonyms
NM_008244, NM_001159328, BC003239,
Species
mouse
UniGene ID
Mm.7919
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.