mouse HBEGF shRNA silencing AAV

Name
AAV-m-HBEGF-shRNA

Cat No
shAAV-261141

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Hbegf.

shAAV-261141

AAV-m-HBEGF-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Hbegf (heparin-binding EGF-like growth factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AW047313; Dtr; Dts; Hegfl

Description (Vector)

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Gene ID

15200

Gene Name (Vector)

heparin-binding EGF-like growth factor

Gene Symbol

Hbegf

ORF Size (aa)

627

ORF Size (bp)

627 bp

RefSeq ID

NM_010415

RefSeq Synonyms

NM_010415, BC089607,

Species

mouse

UniGene ID

Mm.289681

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.