mouse FAM175A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Fam175a.
shAAV-259024
AAV-m-FAM175A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Fam175a (family with sequence similarity 175, member A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3830405G04Rik; 5630400M01Rik; AI506069; AL024423; AV118690; Ccdc98
Description (Vector)
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Gene ID
70681
Gene Name (Vector)
family with sequence similarity 175, member A
Gene Symbol
Fam175a
ORF Size (aa)
897
ORF Size (bp)
897 bp
RefSeq ID
NM_172405
RefSeq Synonyms
NM_172405, BC029845,
Species
mouse
UniGene ID
Mm.221269
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.