mouse FADD shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Fadd.
shAAV-258879
AAV-m-FADD-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Fadd (Fas (TNFRSF6)-associated via death domain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Mort1/FADD
Description (Vector)
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Gene ID
14082
Gene Name (Vector)
Fas (TNFRSF6)-associated via death domain
Gene Symbol
Fadd
ORF Size (aa)
618
ORF Size (bp)
618 bp
RefSeq ID
NM_010175
RefSeq Synonyms
NM_010175, BC021400, BC004584,
Species
mouse
UniGene ID
Mm.5126
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.