mouse ESRP1 shRNA silencing AAV

Name
AAV-m-ESRP1-shRNA

Cat No
shAAV-258718

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Esrp1.

shAAV-258718

AAV-m-ESRP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Esrp1 (epithelial splicing regulatory protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2210008M09Rik; A630065D16; BC031468; Rbm35a

Description (Vector)

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Gene ID

207920

Gene Name (Vector)

epithelial splicing regulatory protein 1

Gene Symbol

Esrp1

ORF Size (aa)

1335

ORF Size (bp)

1335 bp

RefSeq ID

NM_194055

RefSeq Synonyms

NM_194055, NM_001347052, NM_001290383, BC031468,

Species

mouse

UniGene ID

Mm.387719

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.