mouse EPHA1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Epha1.
shAAV-258562
AAV-m-EPHA1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Epha1 (Eph receptor A1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5730453L17Rik; AL033318; Eph; Esk
Description (Vector)
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Gene ID
13835
Gene Name (Vector)
Eph receptor A1
Gene Symbol
Epha1
ORF Size (aa)
2934
ORF Size (bp)
2934 bp
RefSeq ID
NM_023580
RefSeq Synonyms
NM_023580, BC071215,
Species
mouse
UniGene ID
Mm.133330
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.