mouse EIF2AK3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Eif2ak3.
shAAV-258183
AAV-m-EIF2AK3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Pek; Perk
Description (Vector)
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
Gene ID
13666
Gene Name (Vector)
eukaryotic translation initiation factor 2 alpha kinase 3
Gene Symbol
Eif2ak3
ORF Size (aa)
3345
ORF Size (bp)
3345 bp
RefSeq ID
NM_010121
RefSeq Synonyms
NM_010121, NM_001313918, BC054809,
Species
mouse
UniGene ID
Mm.247167
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.