mouse EFNB2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Efnb2.
shAAV-257820
AAV-m-EFNB2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Efnb2 (ephrin B2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5; NLERK-1
Description (Vector)
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Gene ID
13642
Gene Name (Vector)
ephrin B2
Gene Symbol
Efnb2
ORF Size (aa)
1011
ORF Size (bp)
1011 bp
RefSeq ID
NM_010111
RefSeq Synonyms
NM_010111, BC057009,
Species
mouse
UniGene ID
Mm.209813
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.