mouse DOC2B shRNA silencing AAV

Name
AAV-m-DOC2B-shRNA

Cat No
shAAV-257366

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Doc2b.

shAAV-257366

AAV-m-DOC2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Doc2b (double C2, beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).

Gene ID

13447

Gene Name (Vector)

double C2, beta

Gene Symbol

Doc2b

ORF Size (aa)

1239

ORF Size (bp)

1239 bp

RefSeq ID

NM_007873

RefSeq Synonyms

NM_007873, BC067030,

Species

mouse

UniGene ID

Mm.5137

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.