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mouse CYFIP1 shRNA silencing AAV

Name 
AAV-m-CYFIP1-shRNA
Cat No 
shAAV-256450
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Cyfip1.

shAAV-256450
AAV-m-CYFIP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cyfip1 (cytoplasmic FMR1 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1
Description (Vector)
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
Gene ID
20430
Gene Name (Vector)
cytoplasmic FMR1 interacting protein 1
Gene Symbol
Cyfip1
ORF Size (aa)
3756
ORF Size (bp)
3756 bp
RefSeq ID
NM_011370
RefSeq Synonyms
NM_011370, NM_001164662, NM_001164661, BC054429, BC052713, BC047135,
Species
mouse
UniGene ID
Mm.37249

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.