human G6PC Over-expression AAV

Name 
AAV-h-G6PC
Cat No 
AAV-209478
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human G6PC.

AAV-209478
AAV-h-G6PC

Ready-to-use AAV expressing Human G6PC (glucose-6-phosphatase catalytic subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
G6Pase; G6PC1; G6PT; GSD1; GSD1a
Description (Vector)
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.
Gene ID
2538
Gene Name (Vector)
glucose-6-phosphatase catalytic subunit
Gene Symbol
G6PC
HGNC ID
HGNC:4056
ORF Size (aa)
1074
ORF Size (bp)
1074 bp
RefSeq ID
NM_000151
RefSeq Synonyms
NM_001270397, NM_000151, BC136369, BC130478,
Species
human
UniGene ID
Hs.212293

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.