mouse COMP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Comp.
shAAV-255902
AAV-m-COMP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Comp (cartilage oligomeric matrix protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TSP5
Description (Vector)
COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
Gene ID
12845
Gene Name (Vector)
cartilage oligomeric matrix protein
Gene Symbol
Comp
ORF Size (aa)
2268
ORF Size (bp)
2268 bp
RefSeq ID
NM_016685
RefSeq Synonyms
NM_016685, BC128368,
Species
mouse
UniGene ID
Mm.45071
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.