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mouse CLASP2 shRNA silencing AAV

Name 
AAV-m-CLASP2-shRNA
Cat No 
shAAV-255553
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Clasp2.

shAAV-255553
AAV-m-CLASP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Clasp2 (CLIP associating protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1500004F14Rik; 8030404L10Rik; C77448; CLASP2beta; mKIAA0627
Description (Vector)
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Gene ID
76499
Gene Name (Vector)
CLIP associating protein 2
Gene Symbol
Clasp2
ORF Size (aa)
3270
ORF Size (bp)
3270 bp
RefSeq ID
NM_029633
RefSeq Synonyms
NM_029633, NM_001286603, NM_001286602, NM_001286601, NM_001286600, NM_001286599, NM_001114347, NM_001081960, BC141415, BC131792, BC131791, BC117964, BC117963,
Species
mouse
UniGene ID
Mm.222272

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.