mouse CISH shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Cish.
shAAV-255518
AAV-m-CISH-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Cish (cytokine inducible SH2-containing protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cis; CIS-1; CIS1; F17; F23; SOCS
Description (Vector)
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Gene ID
12700
Gene Name (Vector)
cytokine inducible SH2-containing protein
Gene Symbol
Cish
ORF Size (aa)
774
RefSeq ID
NM_009895
RefSeq Synonyms
NM_009895, NM_001317354, BC022178, BC003783,
Species
mouse
UniGene ID
Mm.4592
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.