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mouse CILP shRNA silencing AAV

Name 
AAV-m-CILP-shRNA
Cat No 
shAAV-255508
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Cilp.

shAAV-255508
AAV-m-CILP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cilp (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
9830114D16; C130036G17Rik
Description (Vector)
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Gene ID
214425
Gene Name (Vector)
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Gene Symbol
Cilp
ORF Size (aa)
3555
ORF Size (bp)
3555 bp
RefSeq ID
NM_173385
RefSeq Synonyms
NM_173385, BC080666,
Species
mouse
UniGene ID
Mm.138455

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.