human FOXO3 Over-expression AAV

Name 
AAV-h-FOXO3
Cat No 
AAV-209273
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human FOXO3.

AAV-209273
AAV-h-FOXO3

Ready-to-use AAV expressing Human FOXO3 (forkhead box O3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AF6q21; AF6q21 protein; FKHRL1; FKHRL1P2; forkhead box O3A; forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3A
Description (eCommerce)
Forkhead box protein 03A (FOXO3a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO3a is a transcription factor that functions to induce apoptosis in the absence of survival factors and in response to oxidative stress. Under conditions of oxidative stress FOXO3a is acetylated and localized to the nucleus where it may act as a transcriptional repressor.
Description (Vector)
FOXO3 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXO3 likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
Gene ID
2309
Gene Name (eCommerce)
forkhead box O3
Gene Name (Vector)
forkhead box O3
Gene Symbol
FOXO3
HGNC ID
HGNC:3821
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2022
ORF Size (bp)
2022 bp
Protein Name (eCommerce)
Forkhead box protein O3
RefSeq ID
NM_001455
RefSeq Synonyms
NM_201559, NM_001455, BC068552, BC021224, BC020227,
Research Areas
Aging,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cancer,Cell Cycle,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,FoxO Signaling,Glioma,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Lung Cancer,Metabolism/Metabolic Process,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Translational Control
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,immunology,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Forkhead box protein 03A (FOXO3a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO3a is a transcription factor that functions to induce apoptosis in the absence of survival factors and in response to oxidative stress. Under conditions of oxidative stress FOXO3a is acetylated and localized to the nucleus where it may act as a transcriptional repressor.
UniGene ID
Hs.220950
UniProt ID (eCommerce)
O43524

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.