mouse BRUNOL4 shRNA silencing AAV

Name 
AAV-m-BRUNOL4-shRNA
Cat No 
shAAV-254100
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Celf4.

shAAV-254100
AAV-m-BRUNOL4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Celf4 (CUGBP, Elav-like family member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A230070D14Rik; Brul4; BRUNOL-4; Brunol4; C130060B05Rik
Description (Vector)
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Gene ID
108013
Gene Name (Vector)
CUGBP, Elav-like family member 4
Gene Symbol
Celf4
ORF Size (aa)
1458
ORF Size (bp)
1458 bp
RefSeq ID
NM_133195
RefSeq Synonyms
NM_133195, NM_001174074, NM_001146295, NM_001146294, NM_001146293, NM_001146292, BC052744, BC048405,
Species
mouse
UniGene ID
Mm.266435

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.