mouse BMP10 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Bmp10.
shAAV-254012
AAV-m-BMP10-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Bmp10 (bone morphogenetic protein 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
Gene ID
12154
Gene Name (Vector)
bone morphogenetic protein 10
Gene Symbol
Bmp10
ORF Size (aa)
1266
ORF Size (bp)
1266 bp
RefSeq ID
NM_009756
RefSeq Synonyms
NM_009756, BC145983, BC145044,
Species
mouse
UniGene ID
Mm.57171
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.