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mouse ANK2 shRNA silencing AAV

Name 
AAV-m-ANK2-shRNA
Cat No 
shAAV-252629
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Ank2.

shAAV-252629
AAV-m-ANK2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ank2 (ankyrin 2, brain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
100043364; AI835472; Ank-2; AW491075; Gm4392
Description (Vector)
Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.
Gene ID
109676
Gene Name (Vector)
ankyrin 2, brain
Gene Symbol
Ank2
ORF Size (aa)
3153
ORF Size (bp)
3153 bp
RefSeq ID
NM_178655
RefSeq Synonyms
NM_178655, NM_001327939, NM_001327938, NM_001034168, BC059251,
Species
mouse
UniGene ID
Mm.461850

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.