mouse AKR1A4 shRNA silencing AAV

Name
AAV-m-AKR1A4-shRNA

Cat No
shAAV-252412

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Akr1a1.

shAAV-252412

AAV-m-AKR1A4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Akr1a1 (aldo-keto reductase family 1, member A1 (aldehyde reductase)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2610201A18Rik; Akr1a4

Description (Vector)

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Gene ID

58810

Gene Name (Vector)

aldo-keto reductase family 1, member A1 (aldehyde reductase)

Gene Symbol

Akr1a1

ORF Size (aa)

978

ORF Size (bp)

978 bp

RefSeq ID

NM_021473

RefSeq Synonyms

NM_021473, BC046762, BC039926,

Species

mouse

UniGene ID

Mm.30085

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.