mouse AIRE shRNA silencing AAV

Name
AAV-m-AIRE-shRNA

Cat No
shAAV-252378

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Aire.

shAAV-252378

AAV-m-AIRE-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Aire (autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

Gene ID

11634

Gene Name (Vector)

autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

Gene Symbol

Aire

ORF Size (aa)

954

RefSeq ID

NM_009646

RefSeq Synonyms

NM_009646, NM_001271559, NM_001271558, NM_001271557, NM_001271556, NM_001271555, NM_001271554, NM_001271553, NM_001271552, NM_001271551, NM_001271550, NM_001271549, BC103518, BC103511, BC103510,

Species

mouse

UniGene ID

Mm.35300

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.