mouse PDCD6IP shRNA silencing AAV

Name
AAV-m-PDCD6IP-shRNA

Cat No
shAAV-252301

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Pdcd6ip.

shAAV-252301

AAV-m-PDCD6IP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Pdcd6ip (programmed cell death 6 interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AI480591; Aip1; Alix; AW544830; C76364; Eig2; mKIAA1375

Description (Vector)

Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.

Gene ID

18571

Gene Name (Vector)

programmed cell death 6 interacting protein

Gene Symbol

Pdcd6ip

ORF Size (aa)

2610

ORF Size (bp)

2610 bp

RefSeq ID

NM_011052

RefSeq Synonyms

NM_011052, NM_001164678, NM_001164677, BC051123, BC026823,

Species

mouse

UniGene ID

Mm.29816

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.