mouse ADIPOQ shRNA silencing AAV

Name 
AAV-m-ADIPOQ-shRNA
Cat No 
shAAV-252146
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Adipoq.

shAAV-252146
AAV-m-ADIPOQ-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Adipoq (adiponectin, C1Q and collagen domain containing). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
30kDa; Acdc; Acrp30; Ad; adipo; apM1; APN; GBP28
Description (Vector)
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Gene ID
11450
Gene Name (Vector)
adiponectin, C1Q and collagen domain containing
Gene Symbol
Adipoq
ORF Size (aa)
744
ORF Size (bp)
744 bp
RefSeq ID
NM_009605
RefSeq Synonyms
NM_009605, BC028770,
Species
mouse
UniGene ID
Mm.3969

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.