mouse ABCA4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Abca4.
shAAV-251762
AAV-m-ABCA4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Abca4 (ATP-binding cassette, sub-family A (ABC1), member 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Abc10; Abcr; AW050280; D430003I15Rik; RmP
Description (Vector)
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
Gene ID
11304
Gene Name (Vector)
ATP-binding cassette, sub-family A (ABC1), member 4
Gene Symbol
Abca4
ORF Size (aa)
6933
ORF Size (bp)
6933 bp
RefSeq ID
NM_007378
RefSeq Synonyms
NM_007378, BC057853,
Species
mouse
UniGene ID
Mm.3918
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.