mouse 1520402A15RIK shRNA silencing AAV

Name
AAV-m-1520402A15RIK-shRNA

Cat No
shAAV-250218

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Lurap1.

shAAV-250218

AAV-m-1520402A15RIK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Lurap1 (leucine rich adaptor protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

1520402A15Rik; Lrp35a

Description (Vector)

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).

Gene ID

68075

Gene Name (Vector)

leucine rich adaptor protein 1

Gene Symbol

Lurap1

ORF Size (aa)

720

ORF Size (bp)

720 bp

RefSeq ID

NM_026547

RefSeq Synonyms

NM_026547, BC147750, BC147737, BC147059, BC147058,

Species

mouse

UniGene ID

Mm.388915

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.