human TGFBR2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TGFBR2.
shAAV-234481
AAV-h-TGFBR2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TGFBR2 (transforming growth factor beta receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; tbetaR-II; TBRII; TBR-ii; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta-RII; TGFR-2; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; Transforming growth factor-beta receptor type II
Description (eCommerce)
TGF-beta type II receptor (TGFBR2) is a transmembrane serine/threonine kinase that complexes with the TGF-beta type I serine/threonine kinase receptor (TGFBR1) to form the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. The TGFBR complex transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.The TGFBR is also involved in non-canonical, SMAD-independent TGF-beta signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37173].
Description (Vector)
TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Gene ID
7048
Gene Name (eCommerce)
transforming growth factor beta receptor 2
Gene Name (Vector)
transforming growth factor beta receptor 2
Gene Symbol
TGFBR2
HGNC ID
HGNC:11773
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1776
ORF Size (bp)
1776 bp
Protein Name (eCommerce)
TGF-beta receptor type-2
RefSeq ID
NM_003242
RefSeq Synonyms
NM_003242, NM_001024847, BC152840, BC040499,
Research Areas
Angiogenesis,Apoptosis,Brain Development,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,Colorectal Cancer,EPO Signaling,Hippo Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leukemia,MAPK Signaling,Neurobiology,Neurodevelopment,Signal Transduction,TGF-beta Signaling,Transcriptional Misregulation in Cancer,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
TGF-beta type II receptor (TGFBR2) is a transmembrane serine/threonine kinase that complexes with the TGF-beta type I serine/threonine kinase receptor (TGFBR1) to form the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. The TGFBR complex transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.The TGFBR is also involved in non-canonical, SMAD-independent TGF-beta signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37173].
UniGene ID
Hs.604277
UniProt ID (eCommerce)
P37173
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.