human MBTPS2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MBTPS2.
shAAV-233501
AAV-h-MBTPS2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MBTPS2 (membrane bound transcription factor peptidase, site 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BRESEK; IFAP; KFSD; KFSDX; OLMSX; S2P
Description (Vector)
MBTPS2 encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.
Gene ID
51360
Gene Name (Vector)
membrane bound transcription factor peptidase, site 2
Gene Symbol
MBTPS2
HGNC ID
HGNC:15455
ORF Size (aa)
1560
ORF Size (bp)
1560 bp
RefSeq ID
NM_015884
RefSeq Synonyms
NM_015884, BC036465,
Species
human
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.