human IL17RC shRNA silencing AAV

Name
AAV-h-IL17RC-shRNA

Cat No
shAAV-233390

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human IL17RC.

shAAV-233390

AAV-h-IL17RC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IL17RC (interleukin 17 receptor C). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CANDF9; IL17-RL; IL17RL

Description (Vector)

IL17RC encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.

Gene ID

84818

Gene Name (Vector)

interleukin 17 receptor C

Gene Symbol

IL17RC

HGNC ID

HGNC:18358

ORF Size (aa)

2163

ORF Size (bp)

2163 bp

RefSeq ID

NM_032732

RefSeq Synonyms

NM_153461, NM_153460, NM_032732, NM_001203265, NM_001203264, NM_001203263, BC006411,

Species

human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.