human SNCB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SNCB.
shAAV-232649
AAV-h-SNCB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SNCB (synuclein beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
SNCB is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
Gene ID
6620
Gene Name (Vector)
synuclein beta
Gene Symbol
SNCB
HGNC ID
HGNC:11140
ORF Size (aa)
405
RefSeq ID
NM_001001502
RefSeq Synonyms
NM_003085, NM_001318037, NM_001318036, NM_001318035, NM_001318034, NM_001001502, BC002902,
Species
human
UniGene ID
Hs.90297
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.