human PAX5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PAX5.
shAAV-232432
AAV-h-PAX5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PAX5 (paired box 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALL3; BSAP
Description (Vector)
PAX5 encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. PAX5 encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. PAX5 is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Gene ID
5079
Gene Name (Vector)
paired box 5
Gene Symbol
PAX5
HGNC ID
HGNC:8619
ORF Size (aa)
1173
ORF Size (bp)
1173 bp
RefSeq ID
NM_016734
RefSeq Synonyms
NM_016734, NM_001280556, NM_001280555, NM_001280554, NM_001280553, NM_001280552, NM_001280551, NM_001280550, NM_001280549, NM_001280548, NM_001280547, BC156927, BC156189,
Species
human
UniGene ID
Hs.654464
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.