human RBM5 shRNA silencing AAV

Name 
AAV-h-RBM5-shRNA
Cat No 
shAAV-232350
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RBM5.

shAAV-232350
AAV-h-RBM5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RBM5 (RNA binding motif protein 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
G15; H37; LUCA15; Protein G15; putative tumor suppressor LUCA15; renal carcinoma antigen NY-REN-9; RMB5; RNA-binding motif protein 5; RNA-binding protein 5
Description (eCommerce)
RNA-binding motif protein 5 (RBM5) is also known as LUCA-15. The RBM5 gene is located within a region highly susceptible to deletions in lung cancer and is implicated to be a tumor suppressor. RBM5 bears two RRM domains, one RanBP2-type zinc finger, one C2H2-type zinc finger, and a G-patch domain. It has been found to be a component of the spliceosome, a complex that regulates alternative splicing and is involved in the regulation of proliferation and apoptosis.
Description (Vector)
RBM5 is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. RBM5 is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.
Gene ID
10181
Gene Name (eCommerce)
RNA binding motif protein 5
Gene Name (Vector)
RNA binding motif protein 5
Gene Symbol
RBM5
HGNC ID
HGNC:9902
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2448
ORF Size (bp)
2448 bp
Protein Name (eCommerce)
RNA-binding protein 5
RefSeq ID
NM_005778
RefSeq Synonyms
NM_005778, BC157102, BC156348, BC002957,
Research Areas
Apoptosis,Cancer,Gene Expression,mRNA Binding,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
RNA-binding motif protein 5 (RBM5) is also known as LUCA-15. The RBM5 gene is located within a region highly susceptible to deletions in lung cancer and is implicated to be a tumor suppressor. RBM5 bears two RRM domains, one RanBP2-type zinc finger, one C2H2-type zinc finger, and a G-patch domain. It has been found to be a component of the spliceosome, a complex that regulates alternative splicing and is involved in the regulation of proliferation and apoptosis.
UniGene ID
Hs.
UniProt ID (eCommerce)
P52756

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.