human POLD3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human POLD3.
shAAV-232211
AAV-h-POLD3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human POLD3 (DNA polymerase delta 3, accessory subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA polymerase delta subunit 3; DNA polymerase delta subunit C; DNA polymerase delta subunit p66; DNA polymerase delta subunit p68; P66; P68; Pol delta C subunit (p66); polymerase (DNA) delta 3, accessory subunit; polymerase (DNA-directed), delta 3, accessory subunit; PPP1R128; protein phosphatase 1, regulatory subunit 128
Description (eCommerce)
PolD3/p66 is a subunit of the heterotetrameric DNA polymerase delta that plays a role in DNA replication and repair. The PolD3/p66 subunit has been shown to mediate the interaction between DNA polymerase delta and PCNA (proliferating cell nuclear antigen) to facilitate processivity.
Description (Vector)
POLD3 encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.
Gene ID
10714
Gene Name (eCommerce)
DNA polymerase delta 3, accessory subunit
Gene Name (Vector)
DNA polymerase delta 3, accessory subunit
Gene Symbol
POLD3
HGNC ID
HGNC:20932
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1083
ORF Size (bp)
1083 bp
Protein Name (eCommerce)
DNA polymerase delta subunit 3
RefSeq ID
NM_006591
RefSeq Synonyms
NM_006591, BC108909, BC108908,
Research Areas
Cell Cycle,DNA Damage/Repair,DNA Replication,Homologous Recombination,Host-Virus Interactions,Kinase/Phosphatase,Mitochondrion,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
PolD3/p66 is a subunit of the heterotetrameric DNA polymerase delta that plays a role in DNA replication and repair. The PolD3/p66 subunit has been shown to mediate the interaction between DNA polymerase delta and PCNA (proliferating cell nuclear antigen) to facilitate processivity.
UniGene ID
Hs.
UniProt ID (eCommerce)
Q15054
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.