human PCDHGA8 shRNA silencing AAV

Name
AAV-h-PCDHGA8-shRNA

Cat No
shAAV-232205

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PCDHGA8.

shAAV-232205

AAV-h-PCDHGA8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PCDHGA8 (protocadherin gamma subfamily A, 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PCDH-GAMMA-A8

Description (Vector)

PCDHGA8 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Gene ID

9708

Gene Name (Vector)

protocadherin gamma subfamily A, 8

Gene Symbol

PCDHGA8

HGNC ID

HGNC:8706

ORF Size (aa)

2463

ORF Size (bp)

2463 bp

RefSeq ID

NM_014004

RefSeq Synonyms

NM_032088, NM_014004, BC160101, BC152415,

Species

human

UniGene ID

Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.