human LIMS1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LIMS1.
shAAV-232164
AAV-h-LIMS1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LIMS1 (LIM zinc finger domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PINCH; PINCH-1; PINCH1
Description (Vector)
LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
3987
Gene Name (Vector)
LIM zinc finger domain containing 1
Gene Symbol
LIMS1
HGNC ID
HGNC:6616
ORF Size (aa)
978
ORF Size (bp)
978 bp
RefSeq ID
NM_004987
RefSeq Synonyms
NM_004987, NM_001193488, NM_001193485, NM_001193484, NM_001193483, NM_001193482, BC005341,
Species
human
UniGene ID
Hs.597715
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.