human ABCA1 shRNA silencing AAV

Name
AAV-h-ABCA1-shRNA

Cat No
shAAV-231712

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ABCA1.

shAAV-231712

AAV-h-ABCA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ABCA1 (ATP binding cassette subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ABC-1; ABC1; CERP; HDLDT1; TGD

Description (Vector)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

Gene ID

Gene Name (Vector)

ATP binding cassette subfamily A member 1

Gene Symbol

ABCA1

HGNC ID

HGNC:29

ORF Size (aa)

6786

ORF Size (bp)

6786 bp

RefSeq ID

NM_005502

RefSeq Synonyms

NM_005502, BC146856,

Species

human

UniGene ID

Hs.719214

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.