human CACNB4 shRNA silencing AAV

Name
AAV-h-CACNB4-shRNA

Cat No
shAAV-231518

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CACNB4.

shAAV-231518

AAV-h-CACNB4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6

Description (Vector)

CACNB4 encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

785

Gene Name (Vector)

calcium voltage-gated channel auxiliary subunit beta 4

Gene Symbol

CACNB4

HGNC ID

HGNC:1404

ORF Size (aa)

1563

ORF Size (bp)

1563 bp

RefSeq ID

NM_000726

RefSeq Synonyms

NM_001330118, NM_001330117, NM_001330116, NM_001330115, NM_001330114, NM_001330113, NM_001320722, NM_001145798, NM_001005747, NM_001005746, NM_000726, BC075049,

Species

human

UniGene ID

Hs.120725

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.