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human CXADR shRNA silencing AAV

Name 
AAV-h-CXADR-shRNA
Cat No 
shAAV-230689
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CXADR.

shAAV-230689
AAV-h-CXADR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CXADR (coxsackie virus and adenovirus receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
46 kD coxsackievirus and adenovirus receptor (CAR) protein; CAR; CAR4/6; coxsackie virus and adenovirus receptor; coxsackievirus and adenovirus receptor; coxsackievirus B-adenovirus receptor; CVB3-binding protein; HCAR; HCVADR
Description (eCommerce)
Coxsackievirus and adenovirus receptor (CAR) is a component of the epithelial apical junction complex that is essential for the integrity of tight junctions. CAR is proposed to function as a homophilic cell adhesion molecule. It is also thought to be involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P78310].
Description (Vector)
CXADR is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.
Gene ID
1525
Gene Name (eCommerce)
CXADR, Ig-like cell adhesion molecule
Gene Name (Vector)
coxsackie virus and adenovirus receptor
Gene Symbol
CXADR
HGNC ID
HGNC:2559
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1098
ORF Size (bp)
1098 bp
Protein Name (eCommerce)
Coxsackievirus and adenovirus receptor
RefSeq ID
NM_001338
RefSeq Synonyms
NM_001338, NM_001207066, NM_001207065, NM_001207064, NM_001207063, BC010536, BC003684,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,Cytoskeleton,Host-Virus Interactions,Immunology,Neurobiology,Response to Virus,Signal Transduction
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Coxsackievirus and adenovirus receptor (CAR) is a component of the epithelial apical junction complex that is essential for the integrity of tight junctions. CAR is proposed to function as a homophilic cell adhesion molecule. It is also thought to be involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P78310].
UniGene ID
Hs.634837
UniProt ID (eCommerce)
P78310

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.