human TOM1 shRNA silencing AAV

Name 
AAV-h-TOM1-shRNA
Cat No 
shAAV-230504
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TOM1.

shAAV-230504
AAV-h-TOM1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TOM1 (target of myb1 membrane trafficking protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
target of myb 1; target of Myb protein 1
Description (eCommerce)
TOM1 (target of myb1) was originally identified as a gene activated by the expression of oncogenic Myb1. TOM1 has been shown to form a complex with tollip (toll-interacting protein) and to bind ubiquitin chains. It has also been shown to bind to clathrin heavy chain and is proposed to function to link polyubiquitinated proteins to clathrin and regulate endosomal trafficking of ubiquitinated proteins. Recent evidence shows that TOM1 bridges endofin to clathrin and is critical for the endosomal targeting of clathrin by endofin.
Description (Vector)
TOM1 was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
10043
Gene Name (eCommerce)
target of myb1 membrane trafficking protein
Gene Name (Vector)
target of myb1 membrane trafficking protein
Gene Symbol
TOM1
HGNC ID
HGNC:11982
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
Protein Name (eCommerce)
Target of Myb protein 1
RefSeq ID
NM_005488
RefSeq Synonyms
NM_005488, NM_001135732, NM_001135730, NM_001135729, BC046151,
Research Areas
EGFR Signaling,Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
TOM1 (target of myb1) was originally identified as a gene activated by the expression of oncogenic Myb1. TOM1 has been shown to form a complex with tollip (toll-interacting protein) and to bind ubiquitin chains. It has also been shown to bind to clathrin heavy chain and is proposed to function to link polyubiquitinated proteins to clathrin and regulate endosomal trafficking of ubiquitinated proteins. Recent evidence shows that TOM1 bridges endofin to clathrin and is critical for the endosomal targeting of clathrin by endofin.
UniGene ID
Hs.474705
UniProt ID (eCommerce)
O60784

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.