human CFL1 shRNA silencing AAV

Name
AAV-h-CFL1-shRNA

Cat No
shAAV-230115

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CFL1.

shAAV-230115

AAV-h-CFL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CFL1 (cofilin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CFL; cofilin; HEL-S-15

Description (Vector)

CFL1 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.(supplied by OMIM, Apr 2004)

Gene ID

1072

Gene Name (Vector)

cofilin 1

Gene Symbol

CFL1

HGNC ID

HGNC:1874

ORF Size (aa)

501

ORF Size (bp)

501 bp

RefSeq ID

NM_005507

RefSeq Synonyms

NM_005507, BC018256, BC012318, BC012265, BC011005,

Species

human

UniGene ID

Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.