human UGT1A9 shRNA silencing AAV

Name
AAV-h-UGT1A9-shRNA

Cat No
shAAV-229170

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human UGT1A9.

shAAV-229170

AAV-h-UGT1A9-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UGT1A9 (UDP glucuronosyltransferase family 1 member A9). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I; UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I

Description (Vector)

UGT1A9 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A9 is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.

Gene ID

54600

Gene Name (Vector)

UDP glucuronosyltransferase family 1 member A9

Gene Symbol

UGT1A9

HGNC ID

HGNC:12541

ORF Size (aa)

1593

ORF Size (bp)

1593 bp

RefSeq ID

NM_021027

RefSeq Synonyms

NM_021027, BC058844,

Species

human

UniGene ID

Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.