human SPHK2 shRNA silencing AAV

Name 
AAV-h-SPHK2-shRNA
Cat No 
shAAV-229096
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SPHK2.

shAAV-229096
AAV-h-SPHK2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPHK2 (sphingosine kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SK 2; SK-2; SPK 2; SPK-2
Description (Vector)
SPHK2 encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
56848
Gene Name (Vector)
sphingosine kinase 2
Gene Symbol
SPHK2
HGNC ID
HGNC:18859
ORF Size (aa)
1857
ORF Size (bp)
1857 bp
RefSeq ID
NM_020126
RefSeq Synonyms
NM_020126, NM_001243876, NM_001204160, NM_001204159, NM_001204158, BC010671, BC006161,
Species
human
UniGene ID
Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.