human ZYX shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ZYX.
shAAV-229020
AAV-h-ZYX-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ZYX (zyxin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ESP-2; HED-2
Description (Vector)
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Gene ID
7791
Gene Name (Vector)
zyxin
Gene Symbol
ZYX
HGNC ID
HGNC:13200
ORF Size (aa)
1719
ORF Size (bp)
1719 bp
RefSeq ID
NM_003461
RefSeq Synonyms
NM_003461, NM_001010972, BC010031, BC009360, BC008743,
Species
human
UniGene ID
Hs.490415
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.