human ZNRF2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ZNRF2.
shAAV-228966
AAV-h-ZNRF2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ZNRF2 (zinc and ring finger 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E3 ubiquitin-protein ligase ZNRF2; protein Ells2; RING finger protein 202; RING-type E3 ubiquitin transferase ZNRF2; RNF202; zinc and ring finger 2, E3 ubiquitin protein ligase; zinc finger/RING finger 2; zinc/RING finger protein 2
Description (eCommerce)
Zinc- and RING- finger 2 (ZNRF2) is suggested to play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8NHG8].
Gene ID
223082
Gene Name (eCommerce)
zinc and ring finger 2
Gene Name (Vector)
zinc and ring finger 2
Gene Symbol
ZNRF2
HGNC ID
HGNC:22316
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
729
ORF Size (bp)
729 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase ZNRF2
RefSeq ID
NM_147128
RefSeq Synonyms
NM_147128, BC172400,
Research Areas
Lysosome,Neurobiology,Synapse,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
Zinc- and RING- finger 2 (ZNRF2) is suggested to play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8NHG8].
UniGene ID
Hs.487869
UniProt ID (eCommerce)
Q8NHG8
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.